Findings Waterfall Plots

This report creates waterfall plots to show the distribution of changes in test measurements for a given Findings domain across subjects (ordered by their magnitude of change). The Findings measurements are summarized based on a specified summary statistic and a waterfall plot is created for each Findings test.

Note: JMP Clinical uses a special protocol for data including non-unique Findings test names. Refer to How does JMP Clinical handle non-unique Findings test names? for more information.

Report Results Description

Running Findings Waterfall Plots with the Nicardipine sample setting and LB findings domain generates the report shown below.

Waterfall Plots

There is one Waterfall Plot for each quantitative findings test (for example, laboratory tests) in the Findings data set that was analyzed. Output data set is a stacked data set of findings measurements at subject level; subject level drill downs available.

Use the filter at left to select the finding plot to view. Each plot shows a summary of the findings test measurements on the Y axis for each subject (on X axis) ordered by that measurement. Caption boxes in the upper right corner of each graph (optional) display a summary statistic across all subjects (in a treatment or BY variable group) to aid in understanding the differences in the center/spread of the group distributions.

Options

Data

Domain

Use this widget to specify whether to plot the distribution of measurements from either the Electrocardiogram (EG), Laboratory (LB), or Vital Signs (VS) findings domains.

Findings Tests

Use this widget to select specific Findings tests.

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Click to open the Add window (shown below) that lists available test names (shown below).

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Select the desired test(s) and click OK to add them to the text box.

Subset of Visits to Analyze

Use the Subset of Visits to Analyze option to select the visits to be included in the analysis.

Plot findings measurements as:

Use this widget to specify whether to plot the results either as observed or how they relate to the baseline measurement. Refer to Plot findings measurements as: for more information.

Summary Statistic for Trial Data

Use the Summary Statistic for Trial Data widget to specify whether to display the mean, median, maximum, minimum, or last values to summarize the results of the trial period.

Remove unscheduled visits

You might or might not want to include unscheduled visits when you are analyzing findings by visit. Check the Remove unscheduled visits to exclude unscheduled visits.

Calculate baseline as:

Use the Calculate baseline using: widget to use the last recorded pre-dose measurement or the mean of all the measurements taken during the baseline time window as the baseline measurement.

Snapshot Records to Include

Use this widget to specify which updated snapshot records to include in your analysis. This option is surfaced only in studies where the number of snapshots is greater than 0.

The default state of this option is to show new, modified and stable - effectively all - snapshot records. To see specific records you must remove undesired records from the analysis. For example, to surface only the new records, select both Modified and Stable and click . Click to restore deleted records.

Note: JMP Clinical now relies on the JMP Compare Data Tables platform to detect new records. When duplicate rows appear, the platform evaluates them based on their row order. As a result, records are no longer labeled as Non‑Unique or Previously Non‑Unique, and the corresponding options to include those records have been removed.

Additional Filters - Findings

This filter lets you restrict your analysis to only those subjects that meet specific criteria at the level of the specified Findings domain (EG, LB, or VS) . See Findings for more information.

Note: To filter subjects with a specific event or finding, one could also use the Subpopulation Builder on any domain of interest. For example, filter to all subjects that exhibit cardiac failure ( :Customized Query 01 Name == "Cardiac failure" ) and run all reports on those.

Display

Use this widget to select the findings results to display in the plot.

General and Drill Down Buttons

Action buttons provide you with an easy way to drill down into your data. The following action buttons are generated by this report:

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Click to rerun the report using default settings.

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Click to view the associated data tables. Refer to Show Tables for more information.

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Click to generate a standardized pdf- or rtf-formatted report containing the plots and charts of selected sections.

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Click to generate a JMP Live report. Refer to Create Live Report for more information.

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Click to take notes, and store them in a central location. Refer to Add Notes for more information.

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Click to read user-generated notes. Refer to View Notes for more information.

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Select one or more subjects, then click to apply the Review Subject Filter and filter all reports in the review builder on the selected subjects.

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Select a group of subjects and click to specify Derived Population Flags that enable you to distinguish the selected group of subjects from the general population based on their meeting specific criteria.

Default Settings

Refer to Set Study Preferences for default Subject Level settings.

Methodology

No testing is performed. Analysis is restricted to calculating simple statistics of findings results.